Degree Name

Master of Science (MS)

Semester of Degree Completion

1977

Thesis Director

Eugene B. Krehbiel

Abstract

A total of 38 Mus musculus were used to compare superovulation to normal ovulation in three different areas of the reproductive cycle. The areas studied include the fertilization and abortion rates, alternation of ovarian function, and normalization of estrus cycling. No statistically significant differences were noted between the two groups in either fertility rates or abortion rates. A distinct difference was noted in alternation of ovarian function. Normally ovulating mice showed a distinct right or left preference in the number of ova ovulated from each ovary. Animals showing a left preference exhibited approximately a 2:1 ratio and animals with a right preference exhibited approximately a 3:1 ratio. Superovulated mice showed no preference and exhibited approximately a 1:1 ratio of left to right ova ovulated. A significant difference was also noted in normalization of cycling following mating. There was no significant difference between the normalization rate following normal ovulation as opposed to superovulation treatment. However, when mating occured, a significantly longer time span elapsed before cycling resumed.

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