Degree Name

Master of Science (MS)

Semester of Degree Completion

2002

Thesis Director

Britto P. Nathan

Abstract

Previous studies have demonstrated that 17β-estradiol can modify apolipoprotein E (apoE) expression. I found that apoE protein varied as a function of the estrous cycle and 17β-estradiol (E2) in a region specific manner in the mouse brain. I also found that apoE concentration was lowest on estrus in the hippocampus, cingulate cortex and frontal cortex; apoE concentration was highest on estrus in the olfactory bulb and cerebellum. No changes in apoE were found in the striatum throughout the estrous cycle. Exogenous E2 significantly raised tissue levels in the olfactory bulb and cerebellum, but did not increase apoE in cortical samples nor in the striatum. E2 elevates levels of apoE in a region- and cycle day-specific manner that may be related to the estrogen receptor subtype in that area.

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