Anthony Aya

Document Type

Article

Publication Date

4-10-2025

Abstract

In today’s chemical industries, we are always looking to find a way to make production more efficient and less expensive. In the pharmaceutical industry, the production of common and helpful medicine is essential for profit. Almost all drugs are produced by a series of reactions and bonding to other molecules to make the desired products. One of the most important and common bonds in the molecule structures of these drugs are C-N bonds.

The current catalysis methods for C-N coupling involve high-priced noble metals such as palladium, iridium, or platinum. For example, the most popular method from Buchwald-Hartwig uses a palladium catalyst to perform carbon nitrogen coupling. As this was a great improvement over the previous methods of using strong electron-withdrawing groups to promote nucleophilic aromatic-substitution, it is still not a perfectly efficient method as it still relies on the costly palladium metal.

In this work, we will be building off the work from Chern-Hooi Lim et al who formed a bidental complex with a Bipy ligand and NiBr2•DME. This Ni(II)-Bipy complex has been shown by Chern-Hooi Lim2 to work as an efficient C-N coupling catalyst at room temperature when illuminated by 365-390 nm light for a wide range of reactions between aryl bromide and secondary amines. This method helps remove the costly palladium from the reaction by using a cheaper metal with similar properties such as nickel.

Comments

Undergraduate Division - Honorable Mention

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