Faculty Research and Creative Activity


Ligand Design to Target and Modulate Metal–Protein Interactions in Neurodegenerative Diseases

Document Type


Publication Date

May 2014


Aberrant metal‐protein interactions have been implicated in the pathogenesis of human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Prion disease, Huntington's disease, and amyotrophic lateral sclerosis. Consequently, small molecules capable of targeting and modulating these metal‐protein interactions have been developed as chemical tools to elucidate their links to neurodegeneration and as drug candidates. In this chapter, the approaches employed for designing such molecules are discussed in the context of the current understanding of metal‐protein interactions in multiple neurodegenerative diseases.