Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture

Authors

Aseem Hussain, Eastern Illinois University
Minh Luong, Eastern Illinois University
Apryl Pooley, Eastern Illinois University
Britto P. Nathan, Eastern Illinois UniversityFollow

Document Type

Article

Publication Date

January 2013

Abstract

The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer’s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).

Comments

This open access peer-reviewed article was originally published in the Journal of Biomedical Science, 2013, 20:49, http://www.jbiomedsci.com/content/20/1/49

Recommended Citation

Hussain, Aseem; Luong, Minh; Pooley, Apryl; and Nathan, Britto P., "Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture" (2013). Faculty Research & Creative Activity. 189.
https://thekeep.eiu.edu/bio_fac/189