The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer’s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).
Hussain, Aseem; Luong, Minh; Pooley, Apryl; and Nathan, Britto P., "Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture" (2013). Faculty Research & Creative Activity. Paper 189.